Stable Introduction of a Life-Shortening Wolbachia Infection into the Mosquito Aedes aegypti

@article{McMeniman2009StableIO,
  title={Stable Introduction of a Life-Shortening Wolbachia Infection into the Mosquito Aedes aegypti},
  author={Conor J. McMeniman and Roxanna V Lane and Bodil N Cass and Amy C. C. Fong and Manpreet Sidhu and Yu-Feng Wang and Scott L O'Neill},
  journal={Science},
  year={2009},
  volume={323},
  pages={141 - 144}
}
Most pathogens require a relatively long period of development in their mosquito vector before they can be transmitted to a new human host; hence, only older insects are of epidemiological importance. The successful transfer of a life-shortening strain of the inherited bacterial symbiont, Wolbachia, into the major mosquito vector of dengue, Aedes aegypti, halved adult life span under laboratory conditions. The association is stable, and the Wolbachia strain is maternally inherited at high… Expand
Dynamics of the “Popcorn” Wolbachia Infection in Outbred Aedes aegypti Informs Prospects for Mosquito Vector Control
TLDR
The results were used to assess the potential for wMelPop-CLA to invade natural populations of Ae. Expand
A Wolbachia Symbiont in Aedes aegypti Limits Infection with Dengue, Chikungunya, and Plasmodium
TLDR
It is suggested that this Wolbachia-mediated pathogen interference may work synergistically with the life-shortening strategy proposed previously to provide a powerful approach for the control of insect transmitted diseases. Expand
Identification of Wolbachia Strains in Mosquito Disease Vectors
TLDR
Wolbachia bacteria are identified in Kenyan populations of the yellow fever vector Aedes bromeliae and its relative Aedes metallicus, and in Mansonia uniformis and Mansonia africana, which are vectors of lymphatic filariasis. Expand
The Role of Preferential Mating and Wolbachia Infection on the Aedes Aegypti Population Dynamics
Wolbachia, an endosymbiont bacteria, is common in various invertebrates and known for host reproductive manipulation strategies as well as for slowing the replication of certain viruses. WhenExpand
Wolbachia-mediated virus blocking in the mosquito vector Aedes aegypti.
TLDR
Current hypotheses in the field for the mechanistic basis of pathogen blocking and the evidence from mosquitoes and related insects are discussed and evaluated. Expand
Wolbachia and the biological control of mosquito‐borne disease
TLDR
Wolbachia‐infected Aedes aegypti mosquitoes have been released in areas of Australia in which outbreaks of dengue fever occur, as a prelude to the application of this technology in d Dengue‐endemic areas of south‐east Asia. Expand
CHARACTERIZATION OF WOLBACHIA AND ITS INTERACTION IN HOST MOSQUITOES
TLDR
The results suggest the wAlbB infection in A. aegypti can be an additional agent for Wolbachia-based control strategies, and support the use of these tools to facilitate mass rearing of mosquitoes. Expand
Wolbachia and arbovirus inhibition in mosquitoes.
  • S. Sinkins
  • Biology, Medicine
  • Future microbiology
  • 2013
TLDR
Modulation of autophagy and lipid metabolism, and intracellular competition between viruses and bacteria for lipids, provide promising hypotheses for the mechanism of inhibition in Aedes aegypti. Expand
Life-shortening Wolbachia infection reduces population growth of Aedes aegypti.
TLDR
At high larval densities, wMelPop infected individuals had a significantly reduced population growth rate relative to uninfected individuals, regardless of competition type. Expand
A Virulent Wolbachia Infection Decreases the Viability of the Dengue Vector Aedes aegypti during Periods of Embryonic Quiescence
TLDR
It is suggested that the negative impact of wMelPop-CLA on embryonic quiescence may have applied utility as a tool to reduce mosquito population size in regions with pronounced dry seasons or in regions that experience cool winters. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 23 REFERENCES
Wolbachia Establishment and Invasion in an Aedes aegypti Laboratory Population
TLDR
In this work, stable infections of wAlbB Wolbachia were established in A. aegypti and caused high rates of cytoplasmic incompatibility (that is, elimination of egg hatch), and Laboratory cage tests demonstrated the ability of w albB to spread into an A.A. a egypti population after seeding of an uninfected population with infected females, reaching infection fixation within seven generations. Expand
The potential of virulent Wolbachia to modulate disease transmission by insects.
TLDR
With strong CI and limited effect of fecundity, an introduction of Wolbachia with an initial frequency of 0.4 could result in a 60-80% reduction of transmitting mosquitoes. Expand
Wolbachia-Induced Mortality as a Mechanism to Modulate Pathogen Transmission by Vector Arthropods
TLDR
The results indicate that a broadening of the current paradigm for genetic manipulation of vectors to parameters other than arthropod vector competence is justified and will reveal new research possibilities for vector-borne disease control. Expand
Host Adaptation of a Wolbachia Strain after Long-Term Serial Passage in Mosquito Cell Lines
TLDR
Cell line-adapted wMelPop strains were characterized by a loss of infectivity when reintroduced into the original host, grew to decreased densities, and had reduced abilities to cause life-shortening infection and cytoplasmic incompatibility compared to the original strain. Expand
Wolbachia, normally a symbiont of Drosophila, can be virulent, causing degeneration and early death.
  • K. Min, S. Benzer
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1997
TLDR
A variant Wolbachia carried by Drosophila melanogaster in which this cozy relationship is abrogated is discovered, and tetracycline treatment of carrier flies eliminates both the bacteria and the degeneration, restoring normal life-span. Expand
A Novel Technique for Removing Wolbachia Infections from Aedes albopictus (Diptera: Culicidae)
Abstract Intracellular bacteria of the genus Wolbachia often behave as reproductive parasites by manipulating host reproduction to enhance the vertical transmission of infections. WolbachiaExpand
Wolbachia density and virulence attenuation after transfer into a novel host
TLDR
A strong host involvement in Wolbachia replication rates, the independence of density control responses in different tissues, and the strength of natural selection acting on reproductive fitness are revealed. Expand
Wolbachia and cytoplasmic incompatibility in mosquitoes.
  • S. Sinkins
  • Biology, Medicine
  • Insect biochemistry and molecular biology
  • 2004
TLDR
There are much more comprehensive estimates of the parameters that can affect the spread of Wolbachia through natural populations from low starting frequencies, and for waves of spread to be maintained in the face of partial barriers to gene flow. Expand
Modifying insect population age structure to control vector-borne disease.
TLDR
The recent identification of biological agents that shorten vector lifespan, such as Wolbachia, entomopathogenic fungi and densoviruses, offer new tools for the control of vector-borne diseases. Expand
Effect of temperature on the vector efficiency of Aedes aegypti for dengue 2 virus.
The effect of temperature on the ability of Aedes aegypti to transmit dengue (DEN) 2 virus to rhesus monkeys was assessed as a possible explanation for the seasonal variation in the incidence ofExpand
...
1
2
3
...