Stable Expression of Mosaic Coats of Variant Surface Glycoproteins in Trypanosoma brucei

@article{MuozJordn1996StableEO,
  title={Stable Expression of Mosaic Coats of Variant Surface Glycoproteins in Trypanosoma brucei},
  author={J. Mu{\~n}oz-Jord{\'a}n and K. Davies and G. Cross},
  journal={Science},
  year={1996},
  volume={272},
  pages={1795 - 1797}
}
The paradigm of antigenic variation in parasites is the variant surface glycoprotein (VSG) of African trypanosomes. Only one VSG is expressed at any time, except for short periods during switching. The reasons for this pattern of expression and the consequences of expressing more than one VSG are unknown. Trypanosoma brucei was genetically manipulated to generate cell lines that expressed two VSGs simultaneously. These VSGs were produced in equal amounts and were homogeneously distributed on… Expand
Mechanisms mediating antigenic variation in Trypanosoma brucei.
  • G. Rudenko
  • Biology, Medicine
  • Memorias do Instituto Oswaldo Cruz
  • 1999
University of Dundee Antigenic variation in African trypanosomes
African trypanosomes expressing multiple VSGs are rapidly eliminated by the host immune system
Control of VSG gene expression sites in Trypanosoma brucei.
Control of variant surface glycoprotein gene‐expression sites in Trypanosoma brucei
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