Stabilizing role of calcium store-dependent plasma membrane calcium channels in action-potential firing and intracellular calcium oscillations.

@article{Kusters2005StabilizingRO,
  title={Stabilizing role of calcium store-dependent plasma membrane calcium channels in action-potential firing and intracellular calcium oscillations.},
  author={Johannes M A M Kusters and Marc M. Dernison and Wilbert P M van Meerwijk and Dirk L. Ypey and Alexander P. R. Theuvenet and C. C. A. M. Gielen},
  journal={Biophysical journal},
  year={2005},
  volume={89 6},
  pages={3741-56}
}
In many biological systems, cells display spontaneous calcium oscillations (CaOs) and repetitive action-potential firing. These phenomena have been described separately by models for intracellular inositol trisphosphate (IP3)-mediated CaOs and for plasma membrane excitability. In this study, we present an integrated model that combines an excitable membrane with an IP3-mediated intracellular calcium oscillator. The IP3 receptor is described as an endoplasmic reticulum (ER) calcium channel with… CONTINUE READING

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