Stabilizing insulin-like growth factor-I in poly(D,L-lactide-co-glycolide) microspheres.

  title={Stabilizing insulin-like growth factor-I in poly(D,L-lactide-co-glycolide) microspheres.},
  author={Lorenz Meinel and Oscar E Illi and J W Zapf and Marco Malfanti and H Peter Merkle and Bruno A Gander},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={70 1-2},
This study aimed at developing a controlled drug delivery system for recombinant human insulin-like growth factor-I (IGF-I) for localized delivery in bone healing. IGF-I was microencapsulated into an end-group uncapped 14 kDa poly(D,L-lactide-co-glycolide) 50:50 (PLGA 50:50) by solvent extraction from a W(1)/O/W(2) dispersion. Prior to encapsulation, IGF-I was exposed to ultrasonication in a water/dichloromethane dispersion, and its stability tested in the presence and absence of various… CONTINUE READING


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