Stabilizing effects of some amino acids on membranes of rabbit erythrocytes perturbed by chlorpromazine.

@article{Takeuchi1989StabilizingEO,
  title={Stabilizing effects of some amino acids on membranes of rabbit erythrocytes perturbed by chlorpromazine.},
  author={Yoshikazu Takeuchi and Yumiko Yamaoka and Yasuko Morimoto and I Kaneko and Yoshinobu Fukumori and Tomoaki Fukuda},
  journal={Journal of pharmaceutical sciences},
  year={1989},
  volume={78 1},
  pages={
          3-7
        }
}
Hemolysis experiments indicated that glycine (20 mM) remarkably suppressed the chlorpromazine (CPZ)-induced osmotic permeability enhancing effect in rabbit erythrocytes. Lysine and aspartic acid also showed a similar protecting effect at the same concentration. Thus, the acid-base properties of amino acids were not a determining factor in stabilizing the cell membranes perturbed by CPZ. These results suggest that amino acids stabilize the membranes of the erythrocytes by inhibiting the osmotic… 
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