Stabilizing effect of penicillin G sulfoxide, a competitive inhibitor of penicillin G acylase: its practical applications.

@article{Alvaro1991StabilizingEO,
  title={Stabilizing effect of penicillin G sulfoxide, a competitive inhibitor of penicillin G acylase: its practical applications.},
  author={Giuseppe Alvaro and Roberto Fernandez-Lafuente and Rosa Mar{\'i}a Blanco and Jos{\'e} M Guis{\'a}n},
  journal={Enzyme and microbial technology},
  year={1991},
  volume={13 3},
  pages={210-4}
}
We have found that penicillin G sulfoxide (pen G SO) behaves as a general stabilizing agent of two bacterial penicillin G acylases (PGAs) from E. coli and from K. citrophila), and this role is related to a strong inhibitory effect on the enzymes. The stabilizing effect has been observed during two different inactivation processes: (i) thermal inactivation… CONTINUE READING