Stabilizing amyloid-β peptide by the N-terminus capture is capable of preventing and eliminating amyloid-β oligomers.

Abstract

Elimination of amyloid-β (Aβ) oligomers remains challenging. We describe here a novel strategy to prevent and eliminate the Aβ oligomers from either the early aggregation or the fibril dissolution pathway by targeting the flexible N-terminus, but not the widely investigated hydrophobic segment, with a rationally designed cyclopeptide.

DOI: 10.1039/c7cc03102e

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Cite this paper

@article{Wen2017StabilizingAP, title={Stabilizing amyloid-β peptide by the N-terminus capture is capable of preventing and eliminating amyloid-β oligomers.}, author={Gesi Wen and Daoyuan Chen and Wenjing Qin and Binhua P. Zhou and Youqiao Wang and Ziyi Liu and Jun Du and Qiang Zhou and Junmin Quan and Xianzhang Bu}, journal={Chemical communications}, year={2017}, volume={53 54}, pages={7673-7676} }