Stabilized complexes of epidermal growth factor and its receptor on the cell surface stimulate RNA synthesis but not mitogenesis.

Abstract

Treatment of mouse fibroblasts, prelabeled at 4 degrees C with 125I-labeled epidermal growth factor (EGF), with the lectin concanavalin A (Con A) stabilized the 125I-labeled EGF-receptor complex to dissociation and prevented receptor-mediated endocytosis; after 5 hr at 37 degrees C, approximately 50% of the 125I-labeled EGF initially bound at 4 degrees C… (More)

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@article{Wakshull1985StabilizedCO, title={Stabilized complexes of epidermal growth factor and its receptor on the cell surface stimulate RNA synthesis but not mitogenesis.}, author={E M Wakshull and Walker Wharton}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1985}, volume={82 24}, pages={8513-7} }