Stabilized collagen scaffolds for heart valve tissue engineering.

  title={Stabilized collagen scaffolds for heart valve tissue engineering.},
  author={Mary Elizabeth Tedder and Jun Liao and Benjamin C. Weed and Christopher Stabler and Henry L Zhang and Agneta Simionescu and Dan Teodor Simionescu},
  journal={Tissue engineering. Part A},
  volume={15 6},
Scaffolds for heart valve tissue engineering must function immediately after implantation but also need to tolerate cell infiltration and gradual remodeling. We hypothesized that moderately cross-linked collagen scaffolds would fulfill these requirements. To test our hypothesis, scaffolds prepared from decellularized porcine pericardium were treated with penta-galloyl glucose (PGG), a collagen-binding polyphenol, and tested for biodegradation, biaxial mechanical properties, and in vivo… CONTINUE READING
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