Stabilized HIF-1alpha is superior to VEGF for angiogenesis in skeletal muscle via adeno-associated virus gene transfer.

@article{Pajusola2005StabilizedHI,
  title={Stabilized HIF-1alpha is superior to VEGF for angiogenesis in skeletal muscle via adeno-associated virus gene transfer.},
  author={Katri Pajusola and Jaana K{\"u}nnapuu and Sanna Vuorikoski and Jarkko Soronen and Helder Andr{\'e} and Teresa Pereira and Petra Korpisalo and Seppo Yl{\"a}-Herttuala and Lorenz Poellinger and Kari Alitalo},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2005},
  volume={19 10},
  pages={
          1365-7
        }
}
Therapeutic angiogenesis provides a potential alternative for the treatment of cardiovascular ischemic diseases. Vascular endothelial growth factor (VEGF) is an important component of the angiogenic response to ischemia. Here we used adeno-associated virus (AAV) gene delivery to skeletal muscle to examine the effects of VEGF vs. a stabilized form of hypoxia-inducible factor-1alpha (HIF-1alpha). The recombinant AAVs were injected into mouse tibialis anterior muscle, and their effects were… CONTINUE READING

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