Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II

@article{Deup2011StabilizedGP,
  title={Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II},
  author={X. Deup{\'i} and Patricia Edwards and Ankita Singhal and B. Nickle and D. Oprian and G. Schertler and J. Standfuss},
  journal={Proceedings of the National Academy of Sciences},
  year={2011},
  volume={109},
  pages={119 - 124}
}
  • X. Deupí, Patricia Edwards, +4 authors J. Standfuss
  • Published 2011
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • G protein-coupled receptors (GPCR) are seven transmembrane helix proteins that couple binding of extracellular ligands to conformational changes and activation of intracellular G proteins, GPCR kinases, and arrestins. Constitutively active mutants are ubiquitously found among GPCRs and increase the inherent basal activity of the receptor, which often correlates with a pathological outcome. Here, we have used the M257Y6.40 constitutively active mutant of the photoreceptor rhodopsin in… CONTINUE READING
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 50 REFERENCES
    Crystal structure of rhodopsin: a G-protein-coupled receptor.
    • 4,005
    • Open Access
    Crystal Structure of the β2Adrenergic Receptor-Gs protein complex
    • 1,844
    • Open Access
    Structure of a nanobody-stabilized active state of the β2 adrenoceptor
    • 1,261
    • Open Access
    Crystal structure of opsin in its G-protein-interacting conformation
    • 972
    • Open Access
    Crystal structure of the ligand-free G-protein-coupled receptor opsin
    • 789
    • Open Access
    Crystal structure of metarhodopsin II
    • 552
    • Open Access
    The structural basis of agonist-induced activation in constitutively active rhodopsin
    • 414
    • Open Access
    Structure of bovine rhodopsin in a trigonal crystal form.
    • 700
    • Highly Influential
    • Open Access