Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II.

@article{Deup2012StabilizedGP,
  title={Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II.},
  author={Xavier Deup{\'i} and Patricia Edwards and Ankita Singhal and Benjamin Nickle and Daniel D Oprian and Gebhard F. X. Schertler and Joerg Standfuss},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 1},
  pages={
          119-24
        }
}
G protein-coupled receptors (GPCR) are seven transmembrane helix proteins that couple binding of extracellular ligands to conformational changes and activation of intracellular G proteins, GPCR kinases, and arrestins. Constitutively active mutants are ubiquitously found among GPCRs and increase the inherent basal activity of the receptor, which often correlates with a pathological outcome. Here, we have used the M257Y(6.40) constitutively active mutant of the photoreceptor rhodopsin in… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 88 CITATIONS

FILTER CITATIONS BY YEAR

2012
2018

CITATION STATISTICS

  • 14 Highly Influenced Citations

  • Averaged 9 Citations per year over the last 3 years

  • 9% Increase in citations per year in 2018 over 2017

References

Publications referenced by this paper.
SHOWING 1-10 OF 45 REFERENCES

The structural basis of agonist-induced activation in constitutively active rhodopsin

  • J Standfuss
  • Nature
  • 2011
Highly Influential
20 Excerpts

Crystal structure of metarhodopsin II. Nature 471:651–655

  • HW Choe
  • 2011
Highly Influential
6 Excerpts

Location of the retinal chromophore in the activated state of rhodopsin

  • S Ahuja
  • J Biol Chem
  • 2009
Highly Influential
5 Excerpts

Crystal structure of the beta(2) adrenergic receptor-Gs protein complex

  • SG Rasmussen
  • Nature
  • 2011
2 Excerpts

Structure of a nanobody-stabilized active state of the beta (2) adrenoceptor

  • SG Rasmussen
  • Nature
  • 2011
2 Excerpts

Similar Papers

Loading similar papers…