Stabilization versus inhibition of TAFIa by competitive inhibitors in vitro.

  title={Stabilization versus inhibition of TAFIa by competitive inhibitors in vitro.},
  author={John Bernard Walker and Bernadette A. Hughes and Ian L. James and Peter S. Haddock and Cornelis Kluft and Laszlo Bajzar},
  journal={The Journal of biological chemistry},
  volume={278 11},
Two competitive inhibitors of TAFIa (activated thrombin-activable fibrinolysis inhibitor), 2-guanidinoethylmercaptosuccinic acid and potato tuber carboxypeptidase inhibitor, variably affect fibrinolysis of clotted human plasma. Depending on their concentration, the inhibitors shortened, prolonged, or had no effect on lysis in vitro. The inhibitor-induced effects were both tissue-type plasminogen activator (tPA) and TAFIa concentration-dependent. Inhibitor-dependent prolongation was favored at… CONTINUE READING

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