Stabilization of wild-type p53 by hypoxia-inducible factor 1α

  title={Stabilization of wild-type p53 by hypoxia-inducible factor 1α},
  author={W. An and M. Kanekal and M. Simon and E. Maltepe and M. V. Blagosklonny and L. Neckers},
  • W. An, M. Kanekal, +3 authors L. Neckers
  • Published 1998
  • Biology, Medicine
  • Nature
  • Although hypoxia (lack of oxygen in body tissues) is perhaps the most physiological inducer of the wild-type p53 gene, the mechanism of this induction is unknown. Cells may detect low oxygen levels through a haem-containing sensor protein. The hypoxic state can be mimicked by using cobalt chloride and the iron chelator desferrioxamine: like hypoxia, cobalt chloride and desferrioxamine activate hypoxia-inducible factor 1α (HIF-1α) (ref. 6), which stimulates the transcription of several genes… CONTINUE READING
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