Stabilization of topotecan in low pH liposomes composed of distearoylphosphatidylcholine.


Topotecan is a promising anticancer agent presently undergoing clinical evaluation worldwide. Topotecan, camptothecin, 9-aminocamptothecin, and CPT-11 have aroused considerable interest in recent years for their ability to halt the growth of a wide range of human tumors. For each analogue an important structural requirement for biological activity is a… (More)


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@article{Burke1994StabilizationOT, title={Stabilization of topotecan in low pH liposomes composed of distearoylphosphatidylcholine.}, author={Taylor Burke and Xin Gao}, journal={Journal of pharmaceutical sciences}, year={1994}, volume={83 7}, pages={967-9} }