Stabilization of the Fv fragments in recombinant immunotoxins by disulfide bonds engineered into conserved framework regions.


Disulfide-stabilized Fv's (dsFv's) are recombinant Fv fragments of antibodies in which the unstable variable heavy (VH) and variable light (VL) heterodimers are stabilized by disulfide bonds engineered at specific sites that lie between structurally conserved framework positions of VH and VL. We have recently described one example of a recombinant… (More)


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