• Corpus ID: 32718991

Stabilization of p 53 Is Involved in Quercetin-Induced Cell Cycle Arrest and Apoptosis in HepG 2 Cells

  title={Stabilization of p 53 Is Involved in Quercetin-Induced Cell Cycle Arrest and Apoptosis in HepG 2 Cells},
  author={Shunsuke Tanigawa and Makoto Fujii and De-Xing Hou},
There is evidence for defects in the mechanisms that allow the activation of p53 in many of the cancers that retain wild-type p53. Reactivation of p53 has been suggested to be an effective strategy for cancer therapy in wild-type p53-retained tumor cells. In the present study, we attempted to reactivate p53 in HepG2 retaining wild-type p53 by quercetin, an ubiquitous bioactive plant flavonoid. Our results show that quercetin inhibited the proliferation of HepG2 cells through the induction of… 

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    American journal of physiology. Cell physiology
  • 2001
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