Stabilization of neocarzinostatin nonprotein chromophore activity by interaction with apoprotein and with HeLa cells.

@article{Kappen1980StabilizationON,
  title={Stabilization of neocarzinostatin nonprotein chromophore activity by interaction with apoprotein and with HeLa cells.},
  author={Lizzy S. Kappen and I. H. Goldberg},
  journal={Biochemistry},
  year={1980},
  volume={19 21},
  pages={4786-90}
}
The methanol-extracted, nonprotein chromophore of the protein antibiotic neocarzinostatin (NCS), which possesses the full in vitro and in vivo deoxyribonucleic acid (DNA) strand-breaking activities and the ability to inhibit DNA synthesis and growth in HeLa cells of the holoantibiotic, is much more labile to inactivation by heat, 2-mercaptoethanol, long… CONTINUE READING