Stabilization of mitochondrial function by tetramethylpyrazine protects against kainate-induced oxidative lesions in the rat hippocampus.

@article{Li2010StabilizationOM,
  title={Stabilization of mitochondrial function by tetramethylpyrazine protects against kainate-induced oxidative lesions in the rat hippocampus.},
  author={Shu-yan Li and Yu-Hong Jia and Wen-ge Sun and Yuan Tang and Guo-Shun An and Ju-Hua Ni and Hong-ti Jia},
  journal={Free radical biology & medicine},
  year={2010},
  volume={48 4},
  pages={597-608}
}
Mitochondria are critical regulators of cell death, a key feature of neurodegeneration. Reactive oxygen species (ROS) are crucial to Ca(2+)-mediated effects of glutamate receptor activation leading to neuronal degeneration. Tetramethylpyrazine (TMP) is a principal ingredient of Ligusticum wallichi Franchat (a Chinese herb), used for treatment of cardiovascular and cerebrovascular ischemic diseases. However, its protection against oxidative brain injury associated with excessive activation of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

Tetramethylpyrazine Enhances Vascularization and Prevents Osteonecrosis in Steroid-Treated Rats

BioMed research international • 2015
View 10 Excerpts
Highly Influenced

Tetramethylpyrazine reverses anxiety-like behaviors in a rat model of post-traumatic stress disorder

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology • 2018

Similar Papers

Loading similar papers…