Stabilization of mRNA expression in whole blood samples.

  title={Stabilization of mRNA expression in whole blood samples.},
  author={Lynne Rainen and Uwe Oelmueller and Stewart Jurgensen and Ralf Wyrich and Cynthia Ballas and Jim Schram and Chris M. Herdman and Danute M. Bankaitis-Davis and Nancy Nicholls and David B. Trollinger and Victor Tryon},
  journal={Clinical chemistry},
  volume={48 11},
BACKGROUND Accurate quantification of mRNA in whole blood is made difficult by the simultaneous degradation of gene transcripts and unintended gene induction caused by sample handling or uncontrolled activation of coagulation. This study was designed to compare a new blood collection tube (PAXgene Blood RNA System) and a companion sample preparation reagent set with a traditional sample collection and preparation method for the purpose of gene expression analysis. METHODS We collected… CONTINUE READING
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