Stabilization of low glass transition temperature indomethacin formulations: impact of polymer-type and its concentration.

@article{Chokshi2008StabilizationOL,
  title={Stabilization of low glass transition temperature indomethacin formulations: impact of polymer-type and its concentration.},
  author={Rina J Chokshi and Navnit H. Shah and Harpreet K. Sandhu and A. Waseem Malick and Hossein Zia},
  journal={Journal of pharmaceutical sciences},
  year={2008},
  volume={97 6},
  pages={2286-98}
}
The objectives of this study were to formulate and stabilize amorphous formulation of low T(g) drug (Indomethacin, INM) with selected polymers and compare these formulations based on solubility and dissolution rate studies. Eudragit EPO (EPO), Polyvinylpyrrolidone-vinyl acetate copolymer (PVP-VA), and Polyvinylpyrrolidone K30 (PVPK30) were selected as hydrophilic polymers. The melt extrudates were characterized using differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD… CONTINUE READING