Stabilization of human rhinovirus serotype 2 against pH-induced conformational change by antiviral compounds.

@article{Gruenberger1991StabilizationOH,
  title={Stabilization of human rhinovirus serotype 2 against pH-induced conformational change by antiviral compounds.},
  author={M Gruenberger and Daniel C. Pevear and Gianpietro Diana and Ernst Kuechler and D. Blaas},
  journal={The Journal of general virology},
  year={1991},
  volume={72 ( Pt 2)},
  pages={431-3}
}
Four WIN compounds with anti-picornavirus activities were tested for their ability to stabilize human rhinovirus serotype 2 (HRV-2) against low pH-induced conformational changes in vitro, as determined by specific immunoprecipitation. These results were compared to the minimal inhibitory concentration (MIC) as measured in a plaque reduction assay. A direct… CONTINUE READING