Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex.

  title={Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex.},
  author={Tetsuro Shimakami and Daisuke Yamane and Rohit K. Jangra and Brian J. Kempf and Carolyn Spaniel and David J. Barton and Stanley M Lemon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 3},
MicroRNAs (miRNAs) are small noncoding RNAs that regulate eukaryotic gene expression by binding to regions of imperfect complementarity in mRNAs, typically in the 3' UTR, recruiting an Argonaute (Ago) protein complex that usually results in translational repression or destabilization of the target RNA. The translation and decay of mRNAs are closely linked… CONTINUE READING