Stabilization of helix by side-chain interactions in histatin-derived peptides: role in candidacidal activity.

@article{Ramalingam1996StabilizationOH,
  title={Stabilization of helix by side-chain interactions in histatin-derived peptides: role in candidacidal activity.},
  author={K. Ramalingam and T. Gururaja and N. Ramasubbu and M. Levine},
  journal={Biochemical and biophysical research communications},
  year={1996},
  volume={225 1},
  pages={
          47-53
        }
}
  • K. Ramalingam, T. Gururaja, +1 author M. Levine
  • Published 1996
  • Biology, Medicine
  • Biochemical and biophysical research communications
  • Candida albicans is an opportunistic pathogen prevalent in AIDS patients and oral candidiasis. Azolebased drugs are currently used in the treatment of candidiasis. Histidine-rich peptides (histatins), are the natural inhibitors of candida species present in human salivary secretions. Sequence comparison of histatins revealed the common motif--KRKFHE--in active peptide fragments. Molecular modeling analysis showed structural similarity between this segment of histatins and azole-based drugs. The… CONTINUE READING
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