Stabilization of eukaryotic ribosomal termination complexes by deacylated tRNA

@inproceedings{Susorov2015StabilizationOE,
  title={Stabilization of eukaryotic ribosomal termination complexes by deacylated tRNA},
  author={Denis Susorov and Tatiana Alekseevna Mikhailova and Alexander V Ivanov and Elizaveta Sokolova and Elena Alkalaeva},
  booktitle={Nucleic acids research},
  year={2015}
}
Stabilization of the ribosomal complexes plays an important role in translational control. Mechanisms of ribosome stabilization have been studied in detail for initiation and elongation of eukaryotic translation, but almost nothing is known about stabilization of eukaryotic termination ribosomal complexes. Here, we present one of the mechanisms of fine-tuning of the translation termination process in eukaryotes. We show that certain deacylated tRNAs, remaining in the E site of the ribosome at… CONTINUE READING