Stabilization of eptifibatide by cosolvents.

  title={Stabilization of eptifibatide by cosolvents.},
  author={L. Zhao and S. Yalkowsky},
  journal={International journal of pharmaceutics},
  volume={218 1-2},
Eptifibatide is a potent and highly specific inhibitor of platelet receptor glycoprotein IIb/IIIa and is indicated in the treatment of acute coronary syndrome. The commercial product Integrilin(R) (eptifibatide) Injection requires a cold/refrigerator storage condition. In an effort to improve the drug stability for room temperature storage and transportation, this study proposed a semi-aqueous formulation that contains 2 mg/ml eptifibatide, 10% ethanol, 40% propylene glycol and 50% 0.025 M… Expand
Stabilization and preformulation of anticancer drug--SarCNU.
Spectrofluorimetric determination of eptifibatide in human plasma and dosage form.
Compatibility of argatroban with abciximab, eptifibatide, or tirofiban during simulated Y-site administration.
  • K. Patel, M. J. Hursting
  • Chemistry, Medicine
  • American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
  • 2005
Development, Characterizations and Biocompatibility Evaluations of Intravitreal Lipid Implants


Stability of aspirin in different media.
The amino acid nature of ampicillin and related penicillins.
Kinetics and mechanism of degradation of klerval, a pseudo-tetrapeptide.
Kinetics of degradation in solution of epinephrine by molecular oxygen.
Comparative stability of benzamide, salicylamide, and some N-substituted derivatives.
  • K. Koshy
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • 1969
The kinetics of degradation of chloramphenicol in solution. III. The nature, specific hydrogen ion catalysis, and temperature dependencies of the degradative reactions.
  • T. Higuchi, A. Marcus
  • Chemistry, Medicine
  • Journal of the American Pharmaceutical Association. American Pharmaceutical Association
  • 1954
Hydrolytic behavior of N-acyl phthalimides.
Effects of solvent polarity on the acid dissociation constants of benzoic acids.