Stabilization of eptifibatide by cosolvents.

@article{Zhao2001StabilizationOE,
  title={Stabilization of eptifibatide by cosolvents.},
  author={L. Zhao and S. Yalkowsky},
  journal={International journal of pharmaceutics},
  year={2001},
  volume={218 1-2},
  pages={
          43-56
        }
}
Eptifibatide is a potent and highly specific inhibitor of platelet receptor glycoprotein IIb/IIIa and is indicated in the treatment of acute coronary syndrome. The commercial product Integrilin(R) (eptifibatide) Injection requires a cold/refrigerator storage condition. In an effort to improve the drug stability for room temperature storage and transportation, this study proposed a semi-aqueous formulation that contains 2 mg/ml eptifibatide, 10% ethanol, 40% propylene glycol and 50% 0.025 M… Expand
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