Stabilization of energy charge, generation of oscillations and multiple steady states in energy metabolism as a result of purely stoichiometric regulation.

@article{Selkov1975StabilizationOE,
  title={Stabilization of energy charge, generation of oscillations and multiple steady states in energy metabolism as a result of purely stoichiometric regulation.},
  author={E E Sel'kov},
  journal={European journal of biochemistry},
  year={1975},
  volume={59 1},
  pages={151-7}
}
  • E E Sel'kov
  • Published 1975 in European journal of biochemistry
A simple kinetic model of cell energy metabolism with autocatalytic reaction sequences has beepn analysed. The model accounts for the fact that part of energy produced in the form of ATP, or any other equivalent form, is utilized in "sparking" reactions to activate initial substrates. Analysis of the model shows that energy metabolism, in the absen-e of all non-stoichiometric (i.e. isosteric, cooperative, and allosteric) regulations, is capable of (a) stabilizing, to a high degree of accuracy… CONTINUE READING

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