Stabilization of dry Mammalian cells: lessons from nature.

  title={Stabilization of dry Mammalian cells: lessons from nature.},
  author={John H. Crowe and Lois M. Crowe and Willem F Wolkers and Ann E. Oliver and Xiaocui Ma and J Y Auh and Minke Tang and Shijun Zhu and Jeffrey Norris and Fern Tablin},
  journal={Integrative and comparative biology},
  volume={45 5},
The Center for Biostabilization at UC Davis is attempting to stabilize mammalian cells in the dry state. We review here some of the lessons from nature that we have been applying to this enterprise, including the use of trehalose, a disaccharide found at high concentrations in many anhydrobiotic organisms, to stabilize biological structures, both in vitro and in vivo. Trehalose has useful properties for this purpose and in at least in one case-human blood platelets-introducing this sugar may be… CONTINUE READING