Stabilization of beta-catenin induces pancreas tumor formation.


BACKGROUND & AIMS beta-Catenin signaling within the canonical Wnt pathway is essential for pancreas development. However, the pathway is normally down-regulated in the adult organ. Increased cytoplasmic and nuclear localization of beta-catenin can be detected in nearly all human solid pseudopapillary neoplasms (SPN), a rare tumor with low malignant… (More)
DOI: 10.1053/j.gastro.2008.06.089


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@article{Heiser2008StabilizationOB, title={Stabilization of beta-catenin induces pancreas tumor formation.}, author={Patrick W. Heiser and David A. Cano and Limor Landsman and Grace Kim and James G Kench and David S. Klimstra and Maketo M Taketo and Andrew V. Biankin and Matthias Hebrok}, journal={Gastroenterology}, year={2008}, volume={135 4}, pages={1288-300} }