Stabilization of beta-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast.

@article{Kemler2004StabilizationOB,
  title={Stabilization of beta-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast.},
  author={Rolf Kemler and Andreas Hierholzer and Beno{\^i}t Kanzler and Stefan Kuppig and Kati Hansen and Makoto Mark Taketo and Wilhelmine N. de Vries and Barbara B Knowles and Davor Solter},
  journal={Development},
  year={2004},
  volume={131 23},
  pages={5817-24}
}
Many components of the Wnt/beta-catenin signaling pathway are expressed during mouse pre-implantation embryo development, suggesting that this pathway may control cell proliferation and differentiation at this time. We find no evidence for a functional activity of this pathway in cleavage-stage embryos using the Wnt-reporter line, BAT-gal. To further probe the activity of this pathway, we activated beta-catenin signaling by mating a zona pellucida3-cre (Zp3-cre) transgenic mouse line with a… CONTINUE READING

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