Stabilization of ascorbic acid in human plasma, and its liquid-chromatographic measurement.

  title={Stabilization of ascorbic acid in human plasma, and its liquid-chromatographic measurement.},
  author={Sam A. Margolis and Thomas P Davis},
  journal={Clinical chemistry},
  volume={34 11},
We describe two independent HPLC procedures for the rapid, accurate analysis for ascorbic acid in human plasma. No sample extraction or phase separation is required. We also describe a procedure for preparing a human plasma reference material for use in clinical laboratory analysis for ascorbic acid. The ascorbic acid in plasma can be determined in 15 min, with as little as 50 microL of sample. Analytical recoveries are near 100% with direct injection of deproteinized plasma. Extensive… CONTINUE READING

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