Stabilization of amorphous paracetamol based systems using traditional and novel strategies.

Abstract

There is a special interest in having pharmaceutical active ingredients in the amorphous state due to their increased solubility and therefore, higher bioavailability. Nevertheless, not all of them present stable amorphous phases. In particular, paracetamol is an active ingredient widely known for its instability when prepared in the amorphous state. In the… (More)
DOI: 10.1016/j.ijpharm.2014.10.021

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