Stabilization of alpha-helix structure by polar side-chain interactions: complex salt bridges, cation-pi interactions, and C-H em leader O H-bonds.

@article{Shi2001StabilizationOA,
  title={Stabilization of alpha-helix structure by polar side-chain interactions: complex salt bridges, cation-pi interactions, and C-H em leader O H-bonds.},
  author={Zhengshuang Shi and C Anders Olson and A. J. Bell and Neville R. Kallenbach},
  journal={Biopolymers},
  year={2001},
  volume={60 5},
  pages={366-80}
}
It is generally understood that helical proteins are stabilized by a combination of hydrophobic and packing interactions, together with H-bonds and electrostatic interactions. Here we show that polar side-chain interactions on the surface can play an important role in helix formation and stability. We review studies on model helical peptides that reveal the… CONTINUE READING