Stabilization of active recombinant retroviruses in an amorphous dry state with trehalose.

@article{Bieganski1998StabilizationOA,
  title={Stabilization of active recombinant retroviruses in an amorphous dry state with trehalose.},
  author={Robert M. Bieganski and Audree V. Fowler and Jeffrey R. Morgan and Mehmet Toner},
  journal={Biotechnology progress},
  year={1998},
  volume={14 4},
  pages={615-20}
}
The disaccharide trehalose is found to be effective for stabilization of active recombinant retroviruses in an amorphous dry state achieved through ambient-temperature vacuum dehydration of retroviral supernatants. Studies revealed that trehalose is a significantly better desiccation protectant than sucrose, glucose, and dextran: dextran has essentially no protective effect on retroviral survival after drying and rehydration. X-ray diffractometry of the retroviral supernatant dried with… CONTINUE READING

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