Stabilization of acetylcholine receptors at the neuromuscular synapse: the role of the nerve.

@article{Ramsay1992StabilizationOA,
  title={Stabilization of acetylcholine receptors at the neuromuscular synapse: the role of the nerve.},
  author={David A. Ramsay and Daniel B. Drachman and Raphael Drachman and Elise F. Stanley},
  journal={Brain research},
  year={1992},
  volume={581 2},
  pages={198-207}
}
The majority of acetylcholine receptors (AChRs) at innervated neuromuscular junctions (NMJs) are stable, with half-lives averaging about 11 days in rodent muscles. In addition to the stable AChRs, approximately 18% of AChRs at these innervated junctions are rapidly turned over (RTOs), with half lives of less than 24 h. We have postulated that RTOs may be precursors of stable AChRs, and that the motor nerve may influence their stabilization. This hypothesis was tested by: (i) labeling AChRs in… CONTINUE READING

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