Stabilization of a hydrophobic recombinant cytokine by human serum albumin.

@article{Hawe2007StabilizationOA,
  title={Stabilization of a hydrophobic recombinant cytokine by human serum albumin.},
  author={Andrea Hawe and Wolfgang Friess},
  journal={Journal of pharmaceutical sciences},
  year={2007},
  volume={96 11},
  pages={
          2987-99
        }
}
The objective was to evaluate the impact of pH and NaCl content on aggregation, particle formation, and solubility of a hydrophobic recombinant human cytokine in formulations with human serum albumin (HSA) as stabilizing excipient. While cytokine-HSA formulations were stable at physiological pH, a tremendous increase in turbidity at pH 5.0, close to the isoelectric point of HSA was caused by a partially irreversible precipitation. By dynamic light scattering (DLS), disc centrifugation, atomic… CONTINUE READING
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