Stabilization of a-Conotoxin AuIB : Influences of Disulfide Connectivity and Backbone Cyclization

@inproceedings{Lovelace2014StabilizationOA,
  title={Stabilization of a-Conotoxin AuIB : Influences of Disulfide Connectivity and Backbone Cyclization},
  author={Erica S. Lovelace and Sunithi Gunasekera and Charlotta Alvarmo and Richard J Clark and Simon T. Nevin and A. A. Grishin and David J Adams and David J. Craik and Norelle L Daly},
  year={2014}
}
a-Conotoxins are peptides isolated from the venom ducts of cone snails that target nicotinic acetylcholine receptors (nAChRs). They are valuable pharmacological tools and have potential applications for treating a range of conditions in humans, including pain. However, like all peptides, conotoxins are susceptible to degradation, and to enhance their… CONTINUE READING