Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development.

@article{He2010StabilizationOV,
  title={Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development.},
  author={Yun He and Haifeng Zhang and Luyang Yu and Murat Gunel and Titus J Boggon and Hong Chen and Wang Min},
  journal={Science signaling},
  year={2010},
  volume={3 116},
  pages={ra26}
}
Cerebral cavernous malformations (CCMs) are human vascular malformations caused by mutations in three genes of unknown function: CCM1, CCM2, and CCM3. CCM3, also known as PDCD10 (programmed cell death 10), was initially identified as a messenger RNA whose abundance was induced by apoptotic stimuli in vitro. However, the in vivo function of CCM3 has not been determined. Here, we describe mice with a deletion of the CCM3 gene either ubiquitously or specifically in the vascular endothelium, smooth… CONTINUE READING
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