Stabilization of S-adenosyl-L-methionine promoted by trehalose.


S-adenosyl-L-methionine (SAM), an important metabolic intermediate of mammals, is a well-known therapeutic agent. The molecule is chemically unstable, both in solution and in dry state, and forms different degradation products. Because the chemical instability represents a real problem during the preparation of therapeutic formulations, we investigated the… (More)


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@article{Morana2002StabilizationOS, title={Stabilization of S-adenosyl-L-methionine promoted by trehalose.}, author={Alessandra Morana and Paola Stiuso and Giovanni Colonna and Monica Lamberti and Maria Carten{\'i} and Mario de Rosa}, journal={Biochimica et biophysica acta}, year={2002}, volume={1573 2}, pages={105-8} }