Stabilization of Misoprostol with Hydroxypropyl Methylcellulose (HPMC) Against Degradation by Water

@article{Kararli1990StabilizationOM,
  title={Stabilization of Misoprostol with Hydroxypropyl Methylcellulose (HPMC) Against Degradation by Water},
  author={Tugrul T. Kararli and Thomas Catalano},
  journal={Pharmaceutical Research},
  year={1990},
  volume={7},
  pages={1186-1189}
}
The stability of misoprostol oil is significantly improved in a hydroxypropyl methylcellulose (HPMC) dispersion (1:100). In order to assess the effect of water on misoprostol stability, the rate of misoprostol degradation was investigated in the misoprostol/HPMC dispersion at 55°C, along with the water sorption isotherm, under seven different relative humidity (RH) conditions ranging from 0 to 81%. The results indicated that the first-order rate constants of misoprostol degradation increased in… CONTINUE READING