Stabilization of Hypoxia-Inducible Factor Ameliorates Glomerular Injury Sensitization after Tubulointerstitial Injury.

@article{Zou2020StabilizationOH,
  title={Stabilization of Hypoxia-Inducible Factor Ameliorates Glomerular Injury Sensitization after Tubulointerstitial Injury.},
  author={Jun Zou and Jae Won Yang and Xiaoye Zhu and Jianyong Zhong and Ahmed Nahid Elshaer and Taiji Matsusaka and Ira Pastan and Volker H Haase and Hai-Chun Yang and Agnes B. Fogo},
  journal={Kidney international},
  year={2020}
}
Previously, we found that mild tubulointerstitial injury sensitizes glomeruli to subsequent injury. Here, we evaluated whether stabilization of hypoxia-inducible factor-α (HIF-α), a key regulator of tissue response to hypoxia, ameliorates tubulointerstitial injury and impact on subsequent glomerular injury. Nep25 mice, which express the human CD25 receptor on podocytes under control of the nephrin promotor and develop glomerulosclerosis when a specific toxin is administered were used… 
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