Stabilization of HIF-2α induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth in a murine melanoma model.

@article{Roda2012StabilizationOH,
  title={Stabilization of HIF-2α induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth in a murine melanoma model.},
  author={Julie M. Roda and Yijie Wang and Laura A. Sumner and Gary S. Phillips and Clay B. Marsh and Timothy D. Eubank},
  journal={Journal of immunology},
  year={2012},
  volume={189 6},
  pages={3168-77}
}
Macrophage secretion of vascular endothelial growth factor (VEGF) in response to hypoxia contributes to tumor growth and angiogenesis. In addition to VEGF, hypoxic macrophages stimulated with GM-CSF secrete high levels of a soluble form of the VEGF receptor (sVEGFR-1), which neutralizes VEGF and inhibits its biological activity. Using mice with a monocyte/macrophage-selective deletion of hypoxia-inducible factor (HIF)-1α or HIF-2α, we recently demonstrated that the antitumor response to GM-CSF… CONTINUE READING
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