Stabilization of Foxp3 expression by CRISPR-dCas9-based epigenome editing in mouse primary T cells

@inproceedings{Okada2017StabilizationOF,
  title={Stabilization of Foxp3 expression by CRISPR-dCas9-based epigenome editing in mouse primary T cells},
  author={Masahiro Okada and Mitsuhiro Kanamori and Kazue Someya and Hiroko Nakatsukasa and Akihiko Yoshimura},
  booktitle={Epigenetics & Chromatin},
  year={2017}
}
Epigenome editing is expected to manipulate transcription and cell fates and to elucidate the gene expression mechanisms in various cell types. For functional epigenome editing, assessing the chromatin context-dependent activity of artificial epigenetic modifier is required. In this study, we applied clustered regularly interspaced short palindromic repeats (CRISPR)-dCas9-based epigenome editing to mouse primary T cells, focusing on the Forkhead box P3 (Foxp3) gene locus, a master transcription… CONTINUE READING
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