Stabilization of F-actin by tropomyosin isoforms regulates the morphology and mechanical behavior of red blood cells

Abstract

The short F-actins in the red blood cell (RBC) membrane skeleton are coated along their lengths by an equimolar combination of two tropomyosin isoforms, Tpm1.9 and Tpm3.1. We hypothesized that tropomyosin's ability to stabilize F-actin regulates RBC morphology and mechanical properties. To test this, we examined mice with a targeted deletion in… (More)
DOI: 10.1091/mbc.E16-10-0699

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