Stabilization of Chromatin Structure by PRC1, a Polycomb Complex

  title={Stabilization of Chromatin Structure by PRC1, a Polycomb Complex},
  author={Zhaohui Shao and Florian Raible and Ramin Mollaaghababa and Jeffrey R. Guyon and Chao-Ting Wu and Welcome W. Bender and Robert E. Kingston},
The Polycomb group (PcG) genes are required for maintenance of homeotic gene repression during development. Mutations in these genes can be suppressed by mutations in genes of the SWI/SNF family. We have purified a complex, termed PRC1 (Polycomb repressive complex 1), that contains the products of the PcG genes Polycomb, Posterior sex combs, polyhomeotic, Sex combs on midleg, and several other proteins. Preincubation of PRC1 with nucleosomal arrays blocked the ability of these arrays to be… CONTINUE READING
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