Stabilization of α-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization.

@article{Lovelace2011StabilizationO,
  title={Stabilization of α-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization.},
  author={Erica S. Lovelace and Sunithi Gunasekera and Charlotta Alvarmo and Richard J Clark and Simon T. Nevin and A. A. Grishin and David J Adams and David J. Craik and Norelle L Daly},
  journal={Antioxidants & redox signaling},
  year={2011},
  volume={14 1},
  pages={87-95}
}
α-Conotoxins are peptides isolated from the venom ducts of cone snails that target nicotinic acetylcholine receptors (nAChRs). They are valuable pharmacological tools and have potential applications for treating a range of conditions in humans, including pain. However, like all peptides, conotoxins are susceptible to degradation, and to enhance their… CONTINUE READING