Stabilization and activation of p53 are regulated independently by different phosphorylation events.

@article{Chernov1998StabilizationAA,
  title={Stabilization and activation of p53 are regulated independently by different phosphorylation events.},
  author={M. V. Chernov and C. V. Ramana and V. Adler and G. Stark},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 5},
  pages={
          2284-9
        }
}
  • M. V. Chernov, C. V. Ramana, +1 author G. Stark
  • Published 1998
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • Treatment of mouse or human cells with the protein kinase C (PKC) inhibitors H7 or bisindolylmaleimide I induced an increase in the lifetime of p53, leading to its accumulation. In inhibitor-treated cells, p53 translocated to the nuclei and bound to DNA but was not competent to induce transcription. However, transactivation could be induced by subsequent DNA damage. Phorbol ester, a potent activator of PKC, significantly inhibited the accumulation of p53 after DNA damage. Therefore… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 51 REFERENCES
    Conformation-dependent phosphorylation of p53.
    • 122
    • PDF
    Regulation of p53 stability by Mdm2
    • 3,127