Stabilization Mechanism of Glucose-6-phosphate Dehydrogenase

  title={Stabilization Mechanism of Glucose-6-phosphate Dehydrogenase},
  author={Ekaterina Zaitseva and E. S. Chukhrai and O. M. Poltorak},
Yeast glucose-6-phosphate dehydrogenase (G6PDH) in solutions exists as the equilibrium mixture of dimers and tetramers. Only dimers are active. The equation responding to these conditions was used to determine the parameters: the specific activity of dimers and the dissociation equilibrium constant of tetramers. The stability of G6PDH dimers were shown to be maintained due to the conformational lock, a multiple-point intersubunit contact in the hydrophobic region of “cylindrical” protomers. The… CONTINUE READING

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Modern enzymology: problems and trends

E. A. Zaitzeva, E. S. Chukhrai, O. M. Poltorak
Science publishers. L.-NY • 1995
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and Mosbach K . Biochem

B. Mattiasson

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