Stability study of amorphous valdecoxib.

  title={Stability study of amorphous valdecoxib.},
  author={Anshuman A. Ambike and Kakasaheb Ramoo Mahadik and Anant Paradkar},
  journal={International journal of pharmaceutics},
  volume={282 1-2},
Formulation of poorly water-soluble drugs in the most stable dosage form for oral delivery perhaps presents the greatest challenge to pharmaceutical industry. Physical transformation of drug substance into its more soluble but metastable amorphous form is one of the approaches for improving dissolution rate of such drugs. The present study utilizes technique of spray drying for preparation of solid dispersions (SDs) and includes stability study of the same. Valdecoxib (VLD), a prototype of… CONTINUE READING


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