Stability of the CpG island methylator phenotype during glioma progression and identification of methylated loci in secondary glioblastomas

Abstract

Grade IV glioblastomas exist in two forms, primary (de novo) glioblastomas (pGBM) that arise without precursor lesions, and the less common secondary glioblastomas (sGBM) which develop from earlier lower grade lesions. Genetic heterogeneity between pGBM and sGBM has been documented as have differences in the methylation of individual genes. A… (More)
DOI: 10.1186/1471-2407-14-506

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