Stability of sotalol hydrochloride in extemporaneously prepared oral suspension formulations.

@article{Sidhom2005StabilityOS,
  title={Stability of sotalol hydrochloride in extemporaneously prepared oral suspension formulations.},
  author={Madiha B Sidhom and Nadya Rivera and Hassan Almoazen and David R Taft and Harold L. Kirschenbaum},
  journal={International journal of pharmaceutical compounding},
  year={2005},
  volume={9 5},
  pages={402-6}
}
The physical, chemical, and microbial stabilities of extemporaneously compounded oral liquid formulations of sotalol hydrochloride were studied. Sotalol hydrochloride oral liquid suspensions (5mg/mL) were prepared from commercially available tablets (Betapace) in a 1:1 mixture of Ora-Plus: Ora-Sweet, a 1:1 mixture of Ora-Plus:Ora-Sweet SF, and a 1:2.4 mixture of simple syrup:methylcellulose vehicle. Six batches of each formulation were prepared; three were stored at refrigerated temperature (2… CONTINUE READING

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